Early Life Stress Inhibits Expression of a Novel Innate Immune Pathway in the Developing Hippocampus
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چکیده
منابع مشابه
Early Life Stress Inhibits Expression of Ribosomal RNA in the Developing Hippocampus
Children that are exposed to abuse or neglect show abnormal hippocampal function. However, the developmental mechanisms by which early life stress (ELS) impairs normal hippocampal development have not been elucidated. Here we propose that exposure to ELS blunts normal hippocampal growth by inhibiting the availability of ribosomal RNA (rRNA). In support of this hypothesis, we show that the norma...
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Early-Life Stress Perturbs Key Cellular Programs in the Developing Mouse Hippocampus.
Conflicting reports are available with regard to the effects of childhood abuse and neglect on hippocampal function in children. While earlier imaging studies and some animal work have suggested that the effects of early-life stress (ELS) manifest only in adulthood, more recent studies have documented impaired hippocampal function in maltreated children and adolescents. Additional work using an...
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Early-life stress includes prenatal, postnatal, and adolescence stress. Early-life stress can affect the development of the hypothalamic-pituitary-adrenal (HPA) axis, and cause cellular and molecular changes in the developing hippocampus that can result in neurobehavioral changes later in life. Epidemiological data implicate stress as a cause of seizures in both children and adults. Emerging ev...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2011
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2011.239